Solid dosage formulations of narcotic drugs having improved buccal adsorption

ABSTRACT

Disclosed is a pharmaceutical composition in the form of a tablet suitable for dissolution in the buccal cavity, said composition comprising
         i) an effective amount of a narcotic active ingredient, and   ii) a pharmaceutically acceptable amine having a pK of about 8 or greater,
 
wherein the molar ratio of amine:active ingredient is at least about 5:1.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part of application Ser. No.11/186,925 filed Jul. 22, 2005.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

Not applicable.

BACKGROUND OF THE INVENTION

Buccal formulations are more and more popular for drug administrations.They exhibit in fact several advantages in comparison with other soliddosage forms; in particular, buccal formulations dissolve in the oralcavity without requiring water for ingestion, allowing the buccaladsorption of drugs coming into contact with the oral mucosa indissolved form. Sometimes, buccal administration does not unfortunatelyalways allow to obtain a fast onset of action of the drug, as the resultof difficulties of the drug to cross the skin barrier of mucosa and topenetrate into the blood stream.

DESCRIPTION OF THE INVENTION

The present invention concerns solid dosage formulations of narcoticdrugs having improved buccal adsorption.

The formulations of the invention are characterized by the introductionin a buccal formulation of a pharmaceutically acceptable soluble organiccompound having a primary, secondary or tertiary amine group, having apK of about 8 or greater. Preferably, the in vivo disintegration time oftablets occurs in a time between about 5 and about 25 minutes.

Surprisingly, it has been found that adding a non-toxic orpharmaceutically acceptable amine to a buccal formulation, thepenetration capacity of drugs is significantly improved, allowing toreach a higher and earlier blood concentration of the active ingredientin comparison with formulations without an amine as described herein.

Non-toxic amines having a pK of about 8 or greater which improve thebioavailability according to the invention belong to the followingcategories:

basic amino acids, such as Arginine, Lysine, Histidine, and Omithine;

tertiary amines, such as Triethanolamine, and Thromethamine;

aminosulfonic acids, such as Taurine;

mercapramines such as Cysteamine;

quaternary ammonium salts, such as Betaine;

heterocyclic amines, such as Pyrrolidine; and

Guanidines.

Arginine is a preferred non-toxic amine. The formulations of theinvention may include a mixture of two or more of said amines.Preferably, the amine is not polyvinylpyrrolidone.

Examples of active components that may be advantageously formulated insolid dosage form according to the invention include:

Alfentanil, Buprenorphine, Butorphanol, Codeine, Diphenoxylate,Fentanyl, Heroin, Hydrocodone, Hydromorphone, Oxymorphone, Levophanol,Levallorphan, Loperamide, Meperidine, Morphine, Nalbuphine, Nalmefene,Nalorphine, Naloxone, Naltrexone, Remifentanyl, Sufentanyl andderivatives, salts and analogues thereof. Fentanyl is preferred. Theinvention further includes the use of pharmaceutically acceptable formsof the active ingredient, such as salts, hydrates, etc., for example,Fentanyl citrate.

Preferably, the amount of amine in respect to the active ingredient(molar ratio active ingredient:amine) ranges from about 5:1 to about1000:1, preferably from about 10:1 to about 500:1, and most preferablyfrom about 20:1 to about 250:1.

Preferably, the disintegration time in vivo ranges between about 2 andabout 50 minutes, more preferably between about 5 and about 25 minutes.

It will be understood that the present formulations may additionallycontain ingredients typically found in tablets intended for buccaladministration, such as one or more of diluents, binders, lubricants,glidants, disintegrants, coloring agents, flavouring agents, etc. Thetablets may be made by conventional techniques, including wet, dry orfluid-bed granulation methods, or direct compression. Preferably, thetablets are not lyophilized.

The invention is illustrated by the following non-limiting Examples:

EXAMPLE #1 Example #1A

Preparation of an Oral Dispersible Tablet Containing Amine (Arginine)

Oral dispersible tablets containing 200 mcg of Fentanyl were obtained asfollows:

-   -   A) 1.05 g of Fentanyl citrate and 50 g of PEG 6000 were        dissolved into 90 g of purified water.    -   B) 335.62 g of Sorbitol, 516.67 g of Mannitol, 26.67 g of        aspartame and 10 g of Citric acid, were granulated together with        a water solution containing PEG and Fentanyl citrate.    -   C) At the end of granulation and drying, 43.33 g of arginine        free base and 16.67 g of magnesium stearate were added.    -   D) The product was blended until homogeneity and compressed in        toroidal tablets having a diameter of 10 mm and weighing 300 mg        each and having hardness of about 70 Newton.

Comparative Example #1B

Preparation of an Oral Dispersable Tablet Without Amine

Oral dispersible tablets containing 400 mcg of Fentanyl have beenobtained as follows:

-   -   E) 2.1 g of Fentanyl citrate and 50 g of PEG 6000 were dissolved        into 90 g of purified water.    -   F) 455.62 g of Sorbitol, 455.62 g of Mannitol, 26.67 g of        aspartame and 10 g of Citric acid, were granulated together with        a water solution containing PEG and Fentanyl citrate.    -   G) The product was blended until homogeneity and compressed in        toroidal tablets having a diameter of 10 mm and weighing 300 mg        each having hardness of tablets of 30 Newton.

Example #2

A pharmacokinetic study was carried out on 6 fasting healthy volunteerstreated with a buccal formulation prepared in accordance with example#1A containing 200 mcg of Fentanyl. The results were compared with apharmacokinetic study carried out on 6 healthy volunteers treated with abuccal formulation prepared in accordance with example #1B containing400 mcg of Fentanyl.

The results are reported in the following Table 1:

Fentanyl Disinteg- strength ration per dosage Time in vivo T max C maxAUC Exam- 200 mcg 15 minutes 48 minutes 496 pg/ml 2430 h * ple (pg/ml) #1A Exam- 400 mcg  5 minutes 35 minutes 491 pg/ml 3331 h * ple (pg/ml) #1B

Despite the dose of Fentanyl administered in the tablets described inexample #1A (200 mcg) being 50% of the dose described in example #1B(400 mcg), the pharmacokinetic parameters are similar, demonstrating adramatic improvement of the Fentanyl bioavailability for the formulationof the invention.

Example #3

A pharmacokinetic study was carried out on 6 fasting healthy volunteerstreated with a buccal formulation prepared in accordance with example#1A containing 200 mcg of Fentanyl. The results were compared with apharmacokinetic study carried out on 6 healthy volunteers treated with abuccal formulation commercially available (Actiq-commercialized byCephalon, Inc., Salt Lake City, Utah 84116 USA) containing 200 mcg ofFentanyl.

The results are reported in the following Table 2:

Fentanyl strength Disinteg- per ration dosage Time in vivo T max C maxAUC Exam- 200 mcg 15 minutes 48 minutes 496 pg/ml 2430 h * ple (pg/ml) #1A Actiq 200 mcg 15 minutes 3.25 hours 237 pg/ml 1607 h * (pg/ml)

Despite the dose of Fentanyl administered in the tablets described inexample #1A (200 mcg) being equal to the dose of Actiq (200 mcg), thepharmacokinetic parameters are much higher, demonstrating a dramaticimprovement of the Fentanyl bioavailability for the formulation of theinvention.

The invention claimed is:
 1. A composition in the form of a tabletsuitable for dissolution in the buccal cavity which comprises: about 0.1weight % fentanyl citrate; about 4.3 weight % arginine; about 5.0 weight% PEG 6000; about 33.6 weight % sorbitol; about 51.7 weight % mannitol;about 2.7 weight % aspartame; about 1.0 weight % citric acid; and about1.7 weight % magnesium stearate.
 2. A method of administration of anarcotic to a mammal across the oral mucosa thereof, said methodcomprising orally administering to said mammal a pharmaceuticalcomposition in the form of a tablet suitable for dissolution in thebuccal cavity, said composition comprising: about 0.1 weight % fentanylcitrate; about 4.3 weight % arginine; about 5.0 weight % PEG 6000; about33.6 weight % sorbitol; about 51.7 weight % mannitol; about 2.7 weight %aspartame; about 1.0 weight % citric acid; and about 1.7 weight %magnesium stearate.